Synthetic Approaches to the New Drugs Approved During 2020.
J Med Chem
; 65(14): 9607-9661, 2022 07 28.
Article
em En
| MEDLINE
| ID: mdl-35833579
ABSTRACT
New drugs introduced to the market are privileged structures that have affinities for biological targets implicated in human diseases and conditions. These new chemical entities (NCEs), particularly small molecules and antibody-drug conjugates (ADCs), provide insight into molecular recognition and simultaneously function as leads for the design of future medicines. This Review is part of a continuing series presenting the most likely process-scale synthetic approaches to 44 new chemical entities approved for the first time anywhere in the world during 2020.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
/
Imunoconjugados
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article