Successful use of single-pass albumin dialysis in the correction of severe hyperbilirubinemia in a case of acute hepatitis E.
Ther Apher Dial
; 27(2): 278-283, 2023 Apr.
Article
em En
| MEDLINE
| ID: mdl-35838337
ABSTRACT
INTRODUCTION:
Acute liver failure (ALF) is a rare syndrome defined by the rapid loss of liver function in the absence of pre-existing liver disease, which may be secondary to hepatitis A virus, hepatitis E virus (HEV), or to drugs in about 50% of cases. Extracorporeal albumin dialysis enables the elimination of albumin-bound toxins that accumulate in liver failure.METHODS:
We report a case of ALF secondary to HEV associated with severe hyperbilirubinemia. Patient was treated with four consecutive sessions of single-pass albumin dialysis (SPAD) carried out setting the following parameters time 300 min, Qb 60 mL/min, Qd 800-1000 mL/min, dialysate containing 4% albumin, citrate 3-4 mmol/L.RESULT:
SPAD documented good support of liver function. Bilirubin levels were reduced from 22 to 14 g/dL after four treatments. Pruritus was the first clinical sign of improvement.CONCLUSION:
SPAD system can represent a safe and effective therapeutic option.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hepatite E
/
Falência Hepática Aguda
/
Falência Hepática
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article