Thrombotic microangiopathies: First report of 294 cases from a single institution experience in Argentina.
EJHaem
; 2(2): 149-156, 2021 May.
Article
em En
| MEDLINE
| ID: mdl-35845285
ABSTRACT
Introduction:
Introduction:
Thrombotic microangiopathies (TMAs) are rare disorders associated with fatal outcomes if left uncared for. However, healthcare problems in developing countries tend to limit medical assistance to patients.Methods:
Methods:
We prospectively studied an Argentine cohort of 294 consecutive patients from 2013 to 2016. Patients' subcategory classification relied on clinical symptoms and presence or absence of trigger events associated with TMA.Results:
Main suspected disorders were the primary TMAs known as thrombotic thrombocytopenic purpura (TTP) (n = 72/294, 24%) and atypical haemolytic uraemic syndrome (aHUS) (n = 94/294, 32%). In acute phase, demographic parameters for acquired TTP (aTTP) (n = 28) and aHUS (n = 47) showed that both groups were characterised by a young median age (37 and 25 years, respectively) and female predominance (60% and 86%). Median of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 activity was significantly lower in aTTP than in aHUS group (1.4% vs 83%) and was associated with a more severe thrombocytopenia (15 × 109 vs 53 × 109/L). Creatinine (Cr) and urea (Ur) were significantly increased in aHUS compared to aTTP subjects (Cr 3.7 vs 0.7 mg/dL, Ur 118 vs 33 mg/dL). Gastrointestinal and neurological symptoms were more frequent in aHUS and aTTP, respectively.Conclusion:
The first description of a TMA cohort in Argentina revealed similar clinical presentations to those of other countries.
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MEDLINE
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article