Study of the relationship between FT3, FT4, and TSH with bone resorption indices in men with hypothyroidism.

ABSTRACT

AIM: This study aimed to find the effect of hypothyroidism in men on metabolism and bone mineral density. METHOD: The study included a patients group of 90 men suffering from hypothyroidism and 120 healthy subjects as a control group. The study comprised the estimation of the concentration of Blood free triiodothyronine (FT3), free thyroid hormone (FT4), thyroid stimulating hormone (TSH), bone resorption index type I collagen C-terminal peptide (CTX-1), the serum calcium (Ca2+), serum phosphorus (Pi3+), the bone mineral density of the lumbar spine and femoral neck. RESULTS: In the hypothyroidism men group (1) the bone mass was lower than the control group with significant differences, (2) the bone resorption index CTX-1 was significantly higher than that in the control group and calcium and phosphorus were not different from those in healthy control subjects, and (3) TSH was positively correlated with CTX-1. Male TSH and CTX-1 levels were positively correlated. CONCLUSIONS: There is bone loss in men with hypothyroidism, which may be related to increased bone resorption.