[Research Updates: the role of T follicular helper cells in Sjogren's syndrome].

T follicular helper (Tfh) cells, one of the subsets of CD4+ T cells, play a crucial role in follicles of secondary lymphoid organs. Mature Tfh cells promote the differentiation of B cells into long-lived plasma cells and facilitate immunoglobulin class switch recombination. Recent studies have shown that patients with Sjogren's Syndrome have an increased frequency of Tfh cells in the blood and salivary glands, which are related to the course and severity of the disease. We provides an overview of the differentiation process of Tfh cells, with an emphasis on the distribution, mechanism of action and potential therapeutic importance of Tfh cells in Sjogren's syndrome.