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Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy.
Yang, Jin; Grafton, Francis; Ranjbarvaziri, Sara; Budan, Ana; Farshidfar, Farshad; Cho, Marie; Xu, Emma; Ho, Jaclyn; Maddah, Mahnaz; Loewke, Kevin E; Medina, Julio; Sperandio, David; Patel, Snahel; Hoey, Tim; Mandegar, Mohammad A.
Afiliação
  • Yang J; Tenaya Therapeutics, South San Francisco, CA 94080, USA.
  • Grafton F; Tenaya Therapeutics, South San Francisco, CA 94080, USA.
  • Ranjbarvaziri S; Tenaya Therapeutics, South San Francisco, CA 94080, USA.
  • Budan A; Tenaya Therapeutics, South San Francisco, CA 94080, USA.
  • Farshidfar F; Tenaya Therapeutics, South San Francisco, CA 94080, USA.
  • Cho M; Tenaya Therapeutics, South San Francisco, CA 94080, USA.
  • Xu E; Tenaya Therapeutics, South San Francisco, CA 94080, USA.
  • Ho J; Tenaya Therapeutics, South San Francisco, CA 94080, USA.
  • Maddah M; Dana Solutions, Palo Alto, CA 94306, USA.
  • Loewke KE; Dana Solutions, Palo Alto, CA 94306, USA.
  • Medina J; R2M Pharma, South San Francisco, CA 94080, USA.
  • Sperandio D; R2M Pharma, South San Francisco, CA 94080, USA.
  • Patel S; Tenaya Therapeutics, South San Francisco, CA 94080, USA.
  • Hoey T; Tenaya Therapeutics, South San Francisco, CA 94080, USA.
  • Mandegar MA; Tenaya Therapeutics, South San Francisco, CA 94080, USA.
Sci Transl Med ; 14(652): eabl5654, 2022 07 06.
Article em En | MEDLINE | ID: mdl-35857625
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cardiomiopatia Dilatada / Aprendizado Profundo / Insuficiência Cardíaca Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cardiomiopatia Dilatada / Aprendizado Profundo / Insuficiência Cardíaca Idioma: En Ano de publicação: 2022 Tipo de documento: Article