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Immune correlates of HIV-1 reservoir cell decline in early-treated infants.
Hartana, Ciputra Adijaya; Garcia-Broncano, Pilar; Rassadkina, Yelizaveta; Lian, Xiaodong; Jiang, Chenyang; Einkauf, Kevin B; Maswabi, Kenneth; Ajibola, Gbolahan; Moyo, Sikhulile; Mohammed, Terence; Maphorisa, Comfort; Makhema, Joseph; Yuki, Yuko; Martin, Maureen; Bennett, Kara; Jean-Philippe, Patrick; Viard, Mathias; Hughes, Michael D; Powis, Kathleen M; Carrington, Mary; Lockman, Shahin; Gao, Ce; Yu, Xu G; Kuritzkes, Daniel R; Shapiro, Roger; Lichterfeld, Mathias.
Afiliação
  • Hartana CA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Garcia-Broncano P; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Rassadkina Y; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Lian X; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Jiang C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Einkauf KB; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Maswabi K; Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Ajibola G; Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Moyo S; Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Mohammed T; Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Maphorisa C; Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Makhema J; Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Yuki Y; Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 20892, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Martin M; Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 20892, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Bennett K; Bennett Statistical Consulting, Inc., Ballston Lake, NY 12019, USA.
  • Jean-Philippe P; Division of AIDS, NIAID, NIH, Rockville, MD 20852, USA.
  • Viard M; Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 20892, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Hughes MD; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Powis KM; Harvard Medical School, Boston, MA 02115, USA; Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Medicine and Pediatrics, Massachusetts General Hospital,
  • Carrington M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 20892, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethes
  • Lockman S; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • Gao C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Yu XG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Kuritzkes DR; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Shapiro R; Harvard Medical School, Boston, MA 02115, USA; Botswana - Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Lichterfeld M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: mlichterfeld@partners.org.
Cell Rep ; 40(3): 111126, 2022 07 19.
Article em En | MEDLINE | ID: mdl-35858580
ABSTRACT
Initiation of antiretroviral therapy (ART) in infected neonates within hours after birth limits viral reservoir seeding but does not prevent long-term HIV-1 persistence. Here, we report parallel assessments of HIV-1 reservoir cells and innate antiviral immune responses in a unique cohort of 37 infected neonates from Botswana who started ART extremely early, frequently within hours after birth. Decline of genome-intact HIV-1 proviruses occurs rapidly after initiation of ART and is associated with an increase in natural killer (NK) cell populations expressing the cytotoxicity marker CD57 and with a decrease in NK cell subsets expressing the inhibitory marker NKG2A. Immune perturbations in innate lymphoid cells, myeloid dendritic cells, and monocytes detected at birth normalize after rapid institution of antiretroviral therapy but do not notably influence HIV-1 reservoir cell dynamics. These results suggest that HIV-1 reservoir cell seeding and evolution in early-treated neonates is markedly influenced by antiviral NK cell immune responses.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Soropositividade para HIV Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Soropositividade para HIV Idioma: En Ano de publicação: 2022 Tipo de documento: Article