Fingolimod attenuates gait deficits in mice subjected to experimental autoimmune encephalomyelitis.
J Neuroimmunol
; 370: 577926, 2022 09 15.
Article
em En
| MEDLINE
| ID: mdl-35863299
ABSTRACT
Fingolimod, used to treat relapsing-remitting multiple sclerosis (RRMS), reduces motor deficits in mice with established experimental autoimmune encephalomyelitis (EAE). To better characterize the therapeutic effects of fingolimod, kinematic gait analysis was employed to precisely measure movements of a hindleg while EAE mice walked on a treadmill. Relative to the vehicle group, oral dosing with fingolimod, beginning after disease onset (1 mg/kg/day), increased hip heights and knee joint movements, and reduced spinal cord demyelination. These findings suggest that fingolimod preserves gait in RRMS patients by protecting motor circuits in the spinal cord.
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MEDLINE
Assunto principal:
Esclerose Múltipla Recidivante-Remitente
/
Encefalomielite Autoimune Experimental
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article