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Ultrahigh resolution whole body photon counting computed tomography as a novel versatile tool for translational research from mouse to man.
Wehrse, Eckhard; Klein, Laura; Rotkopf, Lukas Thomas; Stiller, Wolfram; Finke, M; Echner, Gernot G; Glowa, Christin; Heinze, Sarah; Ziener, Christian Herbert; Schlemmer, Heinz Peter; Kachelrieß, Marc; Sawall, Stefan.
Afiliação
  • Wehrse E; Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
  • Klein L; Department of Physics and Astronomy, Heidelberg University, Heidelberg, Germany; Division of X-ray Imaging and CT, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Rotkopf LT; Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Stiller W; Diagnostic and Interventional Radiology (DIR), Heidelberg University Hospital, Heidelberg, Germany.
  • Finke M; Diagnostic and Interventional Radiology (DIR), Heidelberg University Hospital, Heidelberg, Germany.
  • Echner GG; Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.
  • Glowa C; Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Radiation Oncology and Radiotherapy, University Hospital Heidelberg, Heidelberg, Germany; Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Rese
  • Heinze S; Institute of Forensic and Traffic Medicine, University Hospital Heidelberg, Heidelberg, Germany.
  • Ziener CH; Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Schlemmer HP; Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Kachelrieß M; Medical Faculty, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany; Division of X-ray Imaging and CT, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Sawall S; Medical Faculty, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany; Division of X-ray Imaging and CT, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: stefan.sawall@dkfz.de.
Z Med Phys ; 33(2): 155-167, 2023 May.
Article em En | MEDLINE | ID: mdl-35868888
ABSTRACT
X-ray computed tomography (CT) is a cardinal tool in clinical practice. It provides cross-sectional images within seconds. The recent introduction of clinical photon-counting CT allowed for an increase in spatial resolution by more than a factor of two resulting in a pixel size in the center of rotation of about 150 µm. This level of spatial resolution is in the order of dedicated preclinical micro-CT systems. However so far, the need for different dedicated clinical and preclinical systems often hinders the rapid translation of early research results to applications in men. This drawback might be overcome by ultra-high resolution (UHR) clinical photon-counting CT unifying preclinical and clinical research capabilities in a single machine. Herein, the prototype of a clinical UHR PCD CT (SOMATOM CounT, Siemens Healthineers, Forchheim, Germany) was used. The system comprises a conventional energy-integrating detector (EID) and a novel photon-counting detector (PCD). While the EID provides a pixel size of 0.6 mm in the centre of rotation, the PCD provides a pixel size of 0.25 mm. Additionally, it provides a quantification of photon energies by sorting them into up to four distinct energy bins. This acquisition of multi-energy data allows for a multitude of applications, e.g. pseudo-monochromatic imaging. In particular, we examine the relation between spatial resolution, image noise and administered radiation dose for a multitude of use-cases. These cases include ultra-high resolution and multi-energy acquisitions of mice administered with a prototype bismuth-based contrast agent (nanoPET Pharma, Berlin, Germany) as well as larger animals and actual patients. The clinical EID provides a spatial resolution of about 9 lp/cm (modulation transfer function at 10%, MTF10%) while UHR allows for the acquisition of images with up to 16 lp/cm allowing for the visualization of all relevant anatomical structures in preclinical and clinical specimen. The spectral capabilities of the system enable a variety of applications previously not available in preclinical research such as pseudo-monochromatic images. Clinical ultra-high resolution photon-counting CT has the potential to unify preclinical and clinical research on a single system enabling versatile imaging of specimens and individuals ranging from mice to man.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tomografia Computadorizada por Raios X / Pesquisa Translacional Biomédica Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tomografia Computadorizada por Raios X / Pesquisa Translacional Biomédica Idioma: En Ano de publicação: 2023 Tipo de documento: Article