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Revisiting the concept of childhood preleukemia.
Cobaleda, Cesar; Vicente-Dueñas, Carolina; Ramírez-Orellana, Manuel; Sanchez-Garcia, Isidro.
Afiliação
  • Cobaleda C; Immune system development and function Unit, Centro de Biología Molecular Severo Ochoa (CSIC -Universidad Autónoma de Madrid), Madrid, Spain. Electronic address: cesar.cobaleda@csic.es.
  • Vicente-Dueñas C; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
  • Ramírez-Orellana M; Department of Pediatric Hematology and Oncology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address: manuel.ramirez@salud.madrid.org.
  • Sanchez-Garcia I; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca, Salamanca, Spain. Electronic address: isg@usal.es.
Trends Cancer ; 8(11): 887-889, 2022 11.
Article em En | MEDLINE | ID: mdl-35871053
ABSTRACT
Preleukemic has been used to describe children with a propensity to develop B cell acute lymphoblastic leukemia (B-ALL). However, leukemia-predisposing mutations can also be present in differentiated cells unable to transform. We postulate that preleukemia should only be used when such mutations arise in progenitors capable of evolving to B-ALL.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pré-Leucemia / Leucemia-Linfoma Linfoblástico de Células Precursoras Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pré-Leucemia / Leucemia-Linfoma Linfoblástico de Células Precursoras Idioma: En Ano de publicação: 2022 Tipo de documento: Article