Investigation of DPYD, MTHFR and TYMS polymorphisms on 5-fluorouracil related toxicities in colorectal cancer.
Per Med
; 19(5): 435-444, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35880438
5-fluorouracil (5-FU) is a widely used drug for chemotherapy in colorectal cancer. In this study, we investigated the relationship between the severity of 5-FU induced adverse events and several variations in DPYD, MTHFR and TYMS genes, which encode the enzymes involved in 5-FU metabolism in a total of 103 colorectal patients. We also examined the relationship between the polymorphisms and progression-free and overall survival times of the patients in our study group. Among the variations, DPDY 496A>G polymorphism was found to be associated with 5-FU induced adverse events. Also, the DPYD 85T>C polymorphism was detected to be associated with longer progression-free and overall survival times.
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MEDLINE
Assunto principal:
Neoplasias Colorretais
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Di-Hidrouracila Desidrogenase (NADP)
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article