Genetic interaction between Scn8a and potassium channel genes Kcna1 and Kcnq2.
Epilepsia
; 63(10): e125-e131, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-35892317
ABSTRACT
Voltage-gated sodium and potassium channels regulate the initiation and termination of neuronal action potentials. Gain-of-function mutations of sodium channel Scn8a and loss-of-function mutations of potassium channels Kcna1 and Kcnq2 increase neuronal activity and lead to seizure disorders. We tested the hypothesis that reducing the expression of Scn8a would compensate for loss-of-function mutations of Kcna1 or Kcnq2. Scn8a expression was reduced by the administration of an antisense oligonucleotide (ASO). This treatment lengthened the survival of the Kcn1a and Kcnq2 mutants, and reduced the seizure frequency in the Kcnq2 mutant mice. These observations suggest that reduction of SCN8A may be therapeutic for genetic epilepsies resulting from mutations in these potassium channel genes.
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MEDLINE
Assunto principal:
Epilepsia
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Canal de Potássio KCNQ2
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Canal de Potássio Kv1.1
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Canal de Sódio Disparado por Voltagem NAV1.6
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Proteínas do Tecido Nervoso
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article