Last-step 18F-fluorination of supported 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazole conjugates for applications in positron emission tomography.
Chem Commun (Camb)
; 58(65): 9140-9143, 2022 Aug 11.
Article
em En
| MEDLINE
| ID: mdl-35894218
ABSTRACT
Aiming for potential applications in positron emission tomography, fully automated productions of 18F-labelled bioconjugates were achieved using heterogenous precursors obtained by anchoring imidazole-di-tert-butyl-arylsilanes to a polystyrene resin. The reactions were performed using either "batch" or "flow" procedures, avoiding both the time-consuming azeotropic drying and HPLC purifications usually required.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tomografia por Emissão de Pósitrons
/
Halogenação
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article