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The Contribution of Interleukin-8 Rs4073 Genotypes to Triple Negative Breast Cancer Risk in Taiwan.
Wang, Yun-Chi; Wang, Zhi-Hong; Yen, Jung-Hsing; Shen, Yi-Cheng; Shen, Te-Chun; Chang, Wen-Shin; Su, Chen-Hsien; Chen, Kai-Yuan; Yen, Chun-Ming; Lee, Hsu-Tung; Yang, Jai-Sing; Bau, DA-Tian; Tsai, Chia-Wen.
Afiliação
  • Wang YC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
  • Wang ZH; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Yen JH; Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.
  • Shen YC; Division of Plastic and Reconstructive Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
  • Shen TC; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.
  • Chang WS; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Su CH; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Chen KY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
  • Yen CM; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Lee HT; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
  • Yang JS; Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
  • Bau DT; Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
  • Tsai CW; Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
Anticancer Res ; 42(8): 3799-3806, 2022 Aug.
Article em En | MEDLINE | ID: mdl-35896229
ABSTRACT
BACKGROUND/

AIM:

Triple negative breast cancer (TNBC) is one of the most challenging breast cancer types. Interleukin-8 (IL-8) is a pro-tumorigenic cytokine, promoting tumor proliferation and migration. This study aimed to examine the contribution of IL-8 rs4073 genotypes to breast cancer risk and provide a summary of related literature. MATERIALS AND

METHODS:

IL-8 genotypic profiles were determined among 1,232 breast cancer cases and 1,232 controls via polymerase chain reaction-restriction fragment length polymorphism methodology.

RESULTS:

The IL-8 rs4073 AT and AA genotypes had significantly lower prevalence in the case group compared to control group. Allelic frequency analysis showed that individuals carrying the A allele have relatively decreased risk for breast cancer. The stratification analysis showed that IL-8 rs4073 genotypes were protective markers for those with younger (≤55) age.

CONCLUSION:

IL-8 rs4073 A allele is a novel predictor for breast cancer, especially TNBC.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interleucina-8 / Neoplasias de Mama Triplo Negativas Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interleucina-8 / Neoplasias de Mama Triplo Negativas Idioma: En Ano de publicação: 2022 Tipo de documento: Article