Synthesis of Multisubstituted Allylic Alcohols via a Nickel-Catalyzed Cross-Electrophile Ring-Opening Reaction.
Org Lett
; 24(31): 5751-5755, 2022 08 12.
Article
em En
| MEDLINE
| ID: mdl-35901221
ABSTRACT
Herein we report a nickel-catalyzed cross-electrophile ring-opening reaction of vinyl epoxides wherein aryl iodides, alkyl iodides, and benzyl chlorides can all serve as the electrophilic coupling partners, providing a new approach to preparing multisubstituted allylic alcohols. This new method features broad substrate scope (76 examples), good step-economy, and high L/B- and E/Z selectivity as well as mild reaction conditions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Iodetos
/
Níquel
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article