Autoimmune atrophic gastritis and coeliac disease: A case-control study.
Dig Liver Dis
; 55(1): 69-74, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-35906165
ABSTRACT
BACKGROUND:
Autoimmune atrophic gastritis (AAG) is rarely associated with coeliac disease (CD).AIMS:
To assess the frequency of AAG-CD association and to compare clinical, biochemical, and histological features of adults affected by both diseases (cases) with AAG controls.METHODS:
This case-control study included 9 cases (F55%, median age 47, range 23-59yrs) matched (13) by age (±4 yrs) and gender to 27 controls randomly selected from our AAG cohort (2009-2021). The AAG and CD diagnosis was based on internationally agreed criteria.RESULTS:
Of 434 AAG patients (median age62.5yrs, range18-92yrs, FM ratio=2.21),9 had a concomitant diagnosis of CD. The occurrence of AAG-CD association was 2% and 1.65% among AAG/CD cohorts, respectively. Cases were significantly younger than AAG cohort (n = 425, p = 0.002). In 4/9cases, AAG was diagnosed by proactive screening for autoimmune disorders. Autoimmune thyroid disorders were present in 5/9 cases. Cases had a significant higher prevalence of normocytic anaemia than controls (p = 0.004). No significant differences were found between cases and controls concerning clinical and histological features.CONCLUSIONS:
AAG-CD association is rare. Gastric and duodenal biopsies might be advisable in young people with normocytic anaemia and associated autoimmune disorders to timely diagnose clinically silent conditions.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Doença Celíaca
/
Gastrite
/
Gastrite Atrófica
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article