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Chromatographic measurement of 3-hydroxyanthranilate 3,4-dioxygenase activity reveals that edaravone can mitigate the formation of quinolinic acid through a direct enzyme inhibition.
Sanz, Ines; Altomare, Alessandra; Mondanelli, Giada; Protti, Michele; Valsecchi, Valeria; Mercolini, Laura; Volpi, Claudia; Regazzoni, Luca.
Afiliação
  • Sanz I; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133, Milan, Italy.
  • Altomare A; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133, Milan, Italy.
  • Mondanelli G; Department of Medicine and Surgery, University of Perugia, Via Gambuli 1, 06132, Perugia, Italy.
  • Protti M; Research group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy.
  • Valsecchi V; Department of Neuroscience and Reproductive and Odontostomatological Sciences, University of Naples Federico II, Via Pansini 5, 80131, Naples, Italy.
  • Mercolini L; Research group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy.
  • Volpi C; Department of Medicine and Surgery, University of Perugia, Via Gambuli 1, 06132, Perugia, Italy.
  • Regazzoni L; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133, Milan, Italy. Electronic address: luca.regazzoni@unimi.it.
J Pharm Biomed Anal ; 219: 114948, 2022 Sep 20.
Article em En | MEDLINE | ID: mdl-35907317
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Esclerose Lateral Amiotrófica Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Esclerose Lateral Amiotrófica Idioma: En Ano de publicação: 2022 Tipo de documento: Article