Identification of bicyclic compounds that act as dual inhibitors of Bcl-2 and Mcl-1.

Uthale, Abhay; Anantram, Aarti; Sulkshane, Prasad; Degani, Mariam; Teni, Tanuja

Uthale, Abhay; Anantram, Aarti; Sulkshane, Prasad; Degani, Mariam; Teni, Tanuja.

Afiliação

Uthale A; Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, 410 210, India.
Anantram A; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, 400085, India.
Sulkshane P; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, 400 019, India.
Degani M; Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, 410 210, India.
Teni T; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, 400085, India.

Mol Divers ; 27(3): 1359-1374, 2023 Jun.

Article em En | MEDLINE | ID: mdl-35909144

Assuntos

Chalconas; Neoplasias Bucais; Humanos; Chalconas/farmacologia; Proteína bcl-X/metabolismo; Proteína bcl-X/farmacologia; Proteína Killer-Antagonista Homóloga a bcl-2/metabolismo; Proteína Killer-Antagonista Homóloga a bcl-2/farmacologia; Proteínas Reguladoras de Apoptose/metabolismo; Proteínas Reguladoras de Apoptose/farmacologia; Apoptose; Compostos Bicíclicos com Pontes/farmacologia; Benzimidazóis/farmacologia; Linhagem Celular Tumoral

Palavras-chave

Apoptosis; Bcl-2; Benzimidazoles; Flavonoids; Mcl-1; TR-FRET assay

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Chalconas Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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XML

PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Chalconas Idioma: En Ano de publicação: 2023 Tipo de documento: Article