Macrotrabecular-Massive Hepatocellular Carcinoma: Light and Shadow in Current Knowledge.
J Hepatocell Carcinoma
; 9: 661-670, 2022.
Article
em En
| MEDLINE
| ID: mdl-35923611
ABSTRACT
The subject of this narrative review is macrotrabecular-massive hepatocellular carcinoma (MTM-HCC). Despite their rarity, these tumours are of general interest because of their epidemiological and clinical features and for representing a distinct model of the interaction between the angiogenetic system and neoplastic cells. The MTM-HCC subtype is associated with various adverse biological and pathological parameters (the Alfa-foetoprotein (AFP) serum level, tumour size, vascular invasion, and satellite nodules) and is a key determinant of patient prognosis, with a strong and independent predictive value for early and overall tumour recurrence. Gene expression profiling has demonstrated that angiogenesis activation is a hallmark feature of MTM-HCC, with overexpression of both angiopoietin 2 (ANGPT2) and vascular endothelial growth factor A (VEGFA).
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MEDLINE
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En
Ano de publicação:
2022
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Article