Unraveling the interplay between iron homeostasis, ferroptosis and extramedullary hematopoiesis.
Pharmacol Res
; 183: 106386, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35933006
ABSTRACT
Iron participates in myriad processes necessary to sustain life. During the past decades, great efforts have been made to understand iron regulation and function in health and disease. Indeed, iron is associated with both physiological (e.g., immune cell biology and function and hematopoiesis) and pathological (e.g., inflammatory and infectious diseases, ferroptosis and ferritinophagy) processes, yet few studies have addressed the potential functional link between iron, the aforementioned processes and extramedullary hematopoiesis, despite the obvious benefits that this could bring to clinical practice. Further investigation in this direction will shape the future development of individualized treatments for iron-linked diseases and chronic inflammatory disorders, including extramedullary hematopoiesis, metabolic syndrome, cardiovascular diseases and cancer.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hematopoese Extramedular
/
Distúrbios do Metabolismo do Ferro
/
Ferroptose
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article