An intrinsically disordered transcription activation domain increases the DNA binding affinity and reduces the specificity of NF&#954;B p50/RelA.

Baughman, Hannah E R; Narang, Dominic; Chen, Wei; Villagrán Suárez, Amalia C; Lee, Joan; Bachochin, Maxwell J; Gunther, Tristan R; Wolynes, Peter G; Komives, Elizabeth A

An intrinsically disordered transcription activation domain increases the DNA binding affinity and reduces the specificity of NFκB p50/RelA.

Baughman, Hannah E R; Narang, Dominic; Chen, Wei; Villagrán Suárez, Amalia C; Lee, Joan; Bachochin, Maxwell J; Gunther, Tristan R; Wolynes, Peter G; Komives, Elizabeth A.

Afiliação

Baughman HER; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Narang D; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Chen W; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Villagrán Suárez AC; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Lee J; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Bachochin MJ; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Gunther TR; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Wolynes PG; Department of Chemistry and Center for Theoretical Biological Physics, Rice University, Houston, Texas, USA.
Komives EA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA. Electronic address: ekomives@ucsd.edu.

J Biol Chem ; 298(9): 102349, 2022 09.

Article em En | MEDLINE | ID: mdl-35934050

Assuntos

Subunidade p50 de NF-kappa B; Fator de Transcrição RelA; Ativação Transcricional; Sequência de Bases; DNA/química; Subunidade p50 de NF-kappa B/química; Subunidade p50 de NF-kappa B/genética; Ligação Proteica; Domínios Proteicos; Multimerização Proteica; Fator de Transcrição RelA/química; Fator de Transcrição RelA/genética

Palavras-chave

DNA-protein interaction; NF-kB transcription factor; cooperativity; hydrogen-deuterium exchange; intrinsically disordered protein; small-angle X-ray scattering; structural model; transcription

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação Transcricional / Subunidade p50 de NF-kappa B / Fator de Transcrição RelA Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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