Check or Go? Impact of Doubt on the Hierarchical Organization of the Mediofrontal Area.
Biol Psychiatry
; 92(9): 722-729, 2022 11 01.
Article
em En
| MEDLINE
| ID: mdl-35934544
ABSTRACT
BACKGROUND:
Based on numerous imaging and electrophysiological studies, the presupplementary motor area (pre-SMA) and the rostral cingulate motor area are cortical regions considered to be essential to voluntary movement initiation and behavioral control. However, their respective roles and functional interactions remain a long-standing and still debated question.METHODS:
Here, we trained 2 rhesus monkeys (Macaca mulatta) in a complex cognitive task to compare the neuronal activity of these 2 regions on the medial wall during both perceptual and internally guided decisions.RESULTS:
We confirmed the implication of both areas throughout the decision process. Critically, we demonstrate that instead of a stable invariant role, the pre-SMA and rostral cingulate motor area manifested a versatile hierarchical relationship depending on the mode of movement initiation. Whereas pre-SMA neurons were primarily engaged in decisions based on perceptual information, rostral cingulate motor area neurons preempted the decision process in case of an internally doubt-driven checking behavior, withholding pre-SMA recruitment during the time spent inhibiting the habitual action.CONCLUSIONS:
We identified a versatile hierarchical organization of the mediofrontal area that may substantially affect normal and pathological decision processes because adaptive behaviors, such as doubt-checking and its compulsive counterpart, rely on this subtle equilibrium in controlling action initiation.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Córtex Motor
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article