Toxicity evaluation of main zopiclone impurities based on quantitative structure-activity relationship models and in vitro tests.

Yin, Jie; Wen, Hairuo; Chen, Hua

Yin, Jie; Wen, Hairuo; Chen, Hua.

Afiliação

Yin J; National Institutes for Food and Drug Control, Key Laboratory of Chemical Drug Quality Research and Evaluation, National Medical Products Administration, Beijing, China.
Wen H; National Institutes for Food and Drug Control, National Center for Drug Safety Evaluation and Monitoring, Beijing Key Laboratory of Drug Non-clinical Safety Evaluation and Research, Beijing, China.
Chen H; National Institutes for Food and Drug Control, Key Laboratory of Chemical Drug Quality Research and Evaluation, National Medical Products Administration, Beijing, China.

J Appl Toxicol ; 43(2): 230-241, 2023 02.

Article em En | MEDLINE | ID: mdl-35945809

Assuntos

Relação Quantitativa Estrutura-Atividade; Peixe-Zebra; Animais; Mutação; Cromatografia Líquida de Alta Pressão/métodos; Técnicas In Vitro; Contaminação de Medicamentos

Palavras-chave

2-amino-5-chloropyridine; Ames test; degradation impurity; developmental toxicity; genotoxicity; quantitative structure-activity relationship; zopiclone

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Relação Quantitativa Estrutura-Atividade Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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