Epstein-Barr virus-associated smooth muscle tumors in immunocompromised patients: Six case reports.
World J Clin Oncol
; 13(6): 540-552, 2022 Jun 24.
Article
em En
| MEDLINE
| ID: mdl-35949429
ABSTRACT
BACKGROUND:
Epstein-Barr virus associated smooth muscle tumor (EBV-SMT) is a rare oncological entity. However, there is an increasing incidence of EBV-SMTs, as the frequency of organ transplantation and immunosuppression grows. EBV-SMT diagnosis relies on histopathology and immunochemical staining to distinguish it from post-transplant lymphoproliferative disorder (PTLD). There is no clear consensus on the treatment of EBV-SMTs. However, surgical resection, chemotherapy, radiation therapy, and immunosuppression reduction have been explored with varying degrees of success. CASESUMMARY:
Our case series includes six cases of EBV-SMTs across different age groups, with different treatment modalities, adding to the limited existing literature on this rare tumor. The median latency time between immunosuppression and disease diagnosis is four years. EBV-SMTs present with variable degrees of aggressiveness and seem to have worse clinical outcomes in patients with tumor multiplicity and worse immunocompetency.CONCLUSION:
It is imperative to continue building on this knowledge and keeping EBV-SMTs on the differential in immunocompromised individuals.
Case report; Epstein-Barr virus; Epstein-Barr virus-associated smooth muscle tumors; Human immunodeficiency virus; Immunocompromised; Living related kidney transplant; Orthotopic heart transplant; Orthotopic liver transplant; Post-transplant lymphoproliferative disorders; Smooth muscle tumors; Solid Organ Transplant
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MEDLINE
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article