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Association between serum chlamydial antibody levels and tubal infertility in tertiary health facility in South-East Nigeria: a case-control study.
Onyeabochukwu, Augustine D; Izuka, Emmanuel O; Onyegbule, Onyema A; Onumajuru, Chiemeka C; Ejelonu, Uchenna T; Duke-Onyeabo, Chukwunonyerem P; Obiora-Izuka, Chinelo E; Nwagha, Uchenna I.
Afiliação
  • Onyeabochukwu AD; Department of Obstetrics and Gynaecology, Federal Medical Centre, Owerri, Nigeria.
  • Izuka EO; Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu. Nigeria.
  • Onyegbule OA; Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu. Nigeria.
  • Onumajuru CC; Department of Obstetrics and Gynaecology, Federal Medical Centre, Owerri, Nigeria.
  • Ejelonu UT; Department of Obstetrics and Gynaecology, Federal Medical Centre, Owerri, Nigeria.
  • Duke-Onyeabo CP; Department of Obstetrics and Gynaecology, Federal Medical Centre, Owerri, Nigeria.
  • Obiora-Izuka CE; Department of Paediatrics, Enugu State University Teaching Hospital-Parklane, Enugu, Nigeria.
  • Nwagha UI; Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.
Ghana Med J ; 55(3): 183-189, 2021 Sep.
Article em En | MEDLINE | ID: mdl-35950174
Objectives: This study evaluates the association between genital Chlamydial infection and tubal factor infertility in a tertiary health facility in South-East Nigeria. Design: This was a case-control analytical study. Setting: Gynaecology Clinic and Maternity Unit of the Department of Obstetrics and Gynaecology of the Federal Medical Centre (FMC), Owerri, Imo State, Nigeria. Participants: Ninety-six (96) women with confirmed tubal factor infertility served as the cases, and 96 women with normal intra-uterine pregnancy matched in age served as the control. Data Collection/Intervention: A structured questionnaire was used to extract information on the sociodemographic data and the sexual history of the participants. About 2mls of blood was collected, the blood was allowed to clot, and the sera were used for the test. Statistical analysis/Main outcome measure: Pearson Chi-square, Fisher's exact test, likelihood ratio and multivariate logistic regression were used to determine risk associations and identify factors independently related to tubal factor infertility. P-value < 0.05 was considered significant. Results: The sociodemographic characteristics of both cases and control did not differ (P = 0.975). The Chlamydial antibody seropositivity was significantly higher in the cases than the control 78(81.2%) versus 13(13.5%) respectively {(P < 0.001; OR (95% CI) = 27.7(12.7-60.2)}. Only lower abdominal pain {(P = 0.011); OR (95% CI) = 4.3(1.4-13.3)}; was independently associated with tubal factor infertility. Conclusion: Tubal factor infertility is strongly associated with chlamydial IgG antibodies, and a history of lower abdominal pain significantly predicted tubal factor infertility. Funding: The authors paid the cost of procuring the anti-chlamydial ELIZA test kits, plain sample bottles, syringes, gloves and other consumables and stationaries.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Chlamydia trachomatis / Infertilidade Feminina Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Chlamydia trachomatis / Infertilidade Feminina Idioma: En Ano de publicação: 2021 Tipo de documento: Article