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Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.
Amatullah, Hajera; Fraschilla, Isabella; Digumarthi, Sreehaas; Huang, Julie; Adiliaghdam, Fatemeh; Bonilla, Gracia; Wong, Lai Ping; Rivard, Marie-Eve; Beauchamp, Claudine; Mercier, Virginie; Goyette, Philippe; Sadreyev, Ruslan I; Anthony, Robert M; Rioux, John D; Jeffrey, Kate L.
Afiliação
  • Amatullah H; Center for the Study of Inflammatory Bowel Disease, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Fraschilla I; Center for the Study of Inflammatory Bowel Disease, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.
  • Digumarthi S; Center for the Study of Inflammatory Bowel Disease, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA.
  • Huang J; Center for the Study of Inflammatory Bowel Disease, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA.
  • Adiliaghdam F; Center for the Study of Inflammatory Bowel Disease, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Bonilla G; Department of Molecular Biology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Wong LP; Department of Molecular Biology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Rivard ME; Montreal Heart Institute, Montreal, QC H1T 1C8, Canada.
  • Beauchamp C; Montreal Heart Institute, Montreal, QC H1T 1C8, Canada.
  • Mercier V; Montreal Heart Institute, Montreal, QC H1T 1C8, Canada.
  • Goyette P; Montreal Heart Institute, Montreal, QC H1T 1C8, Canada.
  • Sadreyev RI; Department of Molecular Biology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Anthony RM; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Rioux JD; Montreal Heart Institute, Montreal, QC H1T 1C8, Canada.
  • Jeffrey KL; Center for the Study of Inflammatory Bowel Disease, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA. Ele
Cell ; 185(17): 3232-3247.e18, 2022 08 18.
Article em En | MEDLINE | ID: mdl-35952671
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Crohn Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Crohn Idioma: En Ano de publicação: 2022 Tipo de documento: Article