Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment.
Trends Immunol
; 43(9): 687-689, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35963772
ABSTRACT
Interferon regulatory factor 8 (IRF8) has long been associated with conventional dendritic cell type I (cDC1) development. In a recent study, Lança et al. demonstrate that IRF8 is also crucial in cells already committed to the cDC1 lineage. Here, deletion of IRF8 from the XCR1-expressing pre-cDC1 stage onward leads to a loss of commitment and reprogramming of the cells toward a cDC2-like phenotype.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Fatores Reguladores de Interferon
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article