Targeting CRAC channels in inflammatory bowel disease.
EMBO Mol Med
; 14(9): e16489, 2022 09 07.
Article
em En
| MEDLINE
| ID: mdl-35969215
ABSTRACT
Inflammatory bowel disease (IBD) is a collective term for inflammatory diseases of the human gastrointestinal (GI) tract that are characterized by perturbations in the intestinal immune responses. In their study, Letizia et al (2022) found an enrichment of CD4+ effector T cells, interferon gamma (IFNγ) producing CD8+ T cells, regulatory T cells, and innate lymphoid cells (ILC) in the lamina propria (LP) of IBD patients. In these cells, pharmacological inhibition of store-operated calcium entry (SOCE) reduced cytokine production. In addition, in a murine IBD model, systemic SOCE inhibition reduced IBD severity and weight loss.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
/
Canais de Cálcio Ativados pela Liberação de Cálcio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article