Structural Revision of the Stemona Alkaloids Tuberostemonine O, Dehydrocroomines A and B, and Dehydrocroomine.
J Nat Prod
; 85(8): 2110-2115, 2022 08 26.
Article
em En
| MEDLINE
| ID: mdl-35969376
ABSTRACT
The structural revision of four Stemona alkaloids from Stemona tuberosa is reported. The misassignment of the tuberostemonine O structure (1) was recognized when a new alkaloid, tuberostemonine P, was isolated and unambiguously assigned structure 1 in this work. Reinvestigation of the spectroscopic data and NMR calculations led to the revised structure 1a for tuberostemonine O. The structural misassignment of dehydrocroomine A as 2 was corrected by reinterpreting the X-ray crystal structure, which was consistent with 2a. The structural reassignments of dehydrocroomine B (3 to 3a) and dehydrocroomine (4 to 4a) were confirmed by X-ray crystallography and NMR calculations, respectively.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Stemonaceae
/
Alcaloides
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article