Diterpenes from Pinus kesiya var. langbianensis (A.Chev.) Gaussen ex Bui (Pinaceae) and their protective effects in LPS-treated BEAS-2B cells.
Phytochemistry
; 203: 113360, 2022 Nov.
Article
em En
| MEDLINE
| ID: mdl-35970437
ABSTRACT
Eight previously undescribed diterpenoids, rosins A-H, and nine known diterpenoids were isolated from the resin from Pinus kesiya var. langbianensis (A.Chev.) Gaussen ex Bui (Pinaceae) extracted with 95% ethanol. Their structures were determined by nuclear magnetic resonance spectroscopy, mass spectrometry, J-based configuration analysis (JBCA), NOESY spectra, calculated NMR chemical shifts and electronic circular dichroic (ECD) spectra. All compounds were evaluated for their protective effects in LPS-treated human normal lung epithelial cells (BEAS-2B), and the cell viability was significantly increased after treatment with compounds 5, 10, 12, or 15 at a concentration of 10 µM.
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Base de dados:
MEDLINE
Assunto principal:
Pinaceae
/
Pinus
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Diterpenos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article