Classification of early age facial growth pattern and identification of the genetic basis in two Korean populations.
Sci Rep
; 12(1): 13828, 2022 08 15.
Article
em En
| MEDLINE
| ID: mdl-35970861
ABSTRACT
Childhood to adolescence is an accelerated growth period, and genetic features can influence differences of individual growth patterns. In this study, we examined the genetic basis of early age facial growth (EAFG) patterns. Facial shape phenotypes were defined using facial landmark distances, identifying five growth patterns continued-decrease, decrease-to-increase, constant, increase-to-decrease, and continued-increase. We conducted genome-wide association studies (GWAS) for 10 horizontal and 11 vertical phenotypes. The most significant association for horizontal phenotypes was rs610831 (TRIM29; ß = 0.92, p-value = 1.9 × 10-9) and for vertical phenotypes was rs6898746 (ZSWIM6; ß = 0.1103, p-value = 2.5 × 10-8). It is highly correlated with genes already reported for facial growth. This study is the first to classify and characterize facial growth patterns and related genetic polymorphisms.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Face
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Estudo de Associação Genômica Ampla
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Desenvolvimento Maxilofacial
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article