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Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.
Ghiboub, Mohammed; Koster, Jan; Craggs, Peter D; Li Yim, Andrew Y F; Shillings, Anthony; Hutchinson, Sue; Bingham, Ryan P; Gatfield, Kelly; Hageman, Ishtu L; Yao, Gang; O'Keefe, Heather P; Coffin, Aaron; Patel, Amish; Sloan, Lisa A; Mitchell, Darren J; Hayhow, Thomas G; Lunven, Laurent; Watson, Robert J; Blunt, Christopher E; Harrison, Lee A; Bruton, Gordon; Kumar, Umesh; Hamer, Natalie; Spaull, John R; Zwijnenburg, Danny A; Welting, Olaf; Hakvoort, Theodorus B M; Te Velde, Anje A; van Limbergen, Johan; Henneman, Peter; Prinjha, Rab K; de Winther, Menno P J; Harker, Nicola R; Tough, David F; de Jonge, Wouter J.
Afiliação
  • Ghiboub M; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Koster J; Immuno-Epigenetics, Adaptive Immunity Research Unit, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK.
  • Craggs PD; Department of Pediatrics, Division of Pediatric Gastroenterology & Nutrition, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Li Yim AYF; Department of Oncogenomics, Amsterdam University Medical Centers, University of Amsterdam and Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • Shillings A; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Hutchinson S; Immuno-Epigenetics, Adaptive Immunity Research Unit, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK.
  • Bingham RP; Department of Clinical Genetics, Genome Diagnostics Laboratory, Amsterdam Reproduction & Development, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Gatfield K; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Hageman IL; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Yao G; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • O'Keefe HP; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Coffin A; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Patel A; GlaxoSmithKline, Cambridge, MA, USA.
  • Sloan LA; GlaxoSmithKline, Cambridge, MA, USA.
  • Mitchell DJ; Constellation Pharmaceuticals, Cambridge, MA, USA.
  • Hayhow TG; WuXi AppTec, Cambridge, MA, USA.
  • Lunven L; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Watson RJ; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Blunt CE; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Harrison LA; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Bruton G; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Kumar U; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Hamer N; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Spaull JR; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Zwijnenburg DA; Immunology Research Unit, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK.
  • Welting O; Immuno-Epigenetics, Adaptive Immunity Research Unit, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK.
  • Hakvoort TBM; Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK.
  • Te Velde AA; Department of Oncogenomics, Amsterdam University Medical Centers, University of Amsterdam and Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • van Limbergen J; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Henneman P; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Prinjha RK; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • de Winther MPJ; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Harker NR; Department of Pediatrics, Division of Pediatric Gastroenterology & Nutrition, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Tough DF; Department of Clinical Genetics, Genome Diagnostics Laboratory, Amsterdam Reproduction & Development, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • de Jonge WJ; Immunology Research Unit, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK.
BMC Biol ; 20(1): 182, 2022 08 19.
Article em En | MEDLINE | ID: mdl-35986286
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Crohn / Inibidores do Fator de Necrose Tumoral Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Crohn / Inibidores do Fator de Necrose Tumoral Idioma: En Ano de publicação: 2022 Tipo de documento: Article