The perirenal fat thickness was independently associated with serum uric acid level in patients with type 2 diabetes mellitus.
BMC Endocr Disord
; 22(1): 210, 2022 Aug 20.
Article
em En
| MEDLINE
| ID: mdl-35987648
ABSTRACT
BACKGROUND:
Obesity is an important risk factor for hyperuricemia. We aimed to explore the relationship between perirenal fat thickness (PrFT) and paranephric fat thickness (PnFT) and serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM).METHODS:
This was a cross-sectional study involving 257 patients with T2DM recruited from Beijing Luhe Hospital from September 2019 to May 2020. The basic and clinical information such as age, gender, duration of diabetes was collected through the medical records. All patients underwent a physical examination including height, weight, waist circumference, hip circumference, systolic blood pressures and diastolic blood pressure. The venous blood and urine samples were collected to measure SUA, fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, serum creatinine, blood urea nitrogen and glycosylated hemoglobin. PrFT and PnFT were measured via ultrasonography. Pearson correlation test and linear regression analysis were used to analyze the association between PrFT and PnFT and SUA.RESULTS:
We found that PrFT and PnFT increased according to the tertiles of SUA level (P = 0.001 and P = 0.009, respectively). In addition, the PrFT and PnFT were positively associated with SUA level (r = 0.25, P < 0.001, r = 0.23, P < 0.001, respectively). Moreover, this association was stronger in males, non-obesity patients and patients with normal renal function. In the multivariate analysis, the PrFT was independently associated with SUA level after adjusting confounding factors.CONCLUSIONS:
The PrFT was independently associated with SUA level in patients with T2DM.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ácido Úrico
/
Diabetes Mellitus Tipo 2
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article