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Adipocyte plasticity in tissue regeneration, repair, and disease.
Horsley, Valerie.
Afiliação
  • Horsley V; Department of Molecular and Cell Biology, Yale University, New Haven, CT, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA. Electronic address: valerie.horsley@yale.edu.
Curr Opin Genet Dev ; 76: 101968, 2022 10.
Article em En | MEDLINE | ID: mdl-35988318
ABSTRACT
Mammalian tissue repair forms a scar that fills the injured area with a fibrotic lesion, limiting tissue function. Adipocytes, lipid-filled cells, well-known for energy storage and endocrine functions, can reside adjacent to or within many tissues, and are emerging as critical regulators of tissue repair. In this review, the plasticity and function of adipocytes to tissue repair and fibrosis in four tissues skin, heart, skeletal muscle, and mammary gland, will be discussed. The dynamic nature of adipocytes as they release bioactive products, lipids, and adipokines, and their ability to form contractile fibroblasts, is emerging as an essential regulator of wound healing and tumorigenesis in multiple tissues. Thus, modulation of adipocytes may provide therapeutic avenues for regenerative medicine and cancer.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicatrização / Adipócitos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicatrização / Adipócitos Idioma: En Ano de publicação: 2022 Tipo de documento: Article