Patent landscape of inhibitors and PROTACs of the anti-apoptotic BCL-2 family proteins.

Pal, Pratik; Zhang, Peiyi; Poddar, Saikat K; Zheng, Guangrong

Pal, Pratik; Zhang, Peiyi; Poddar, Saikat K; Zheng, Guangrong.

Afiliação

Pal P; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Zhang P; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Poddar SK; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Zheng G; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.

Expert Opin Ther Pat ; 32(9): 1003-1026, 2022 Sep.

Article em En | MEDLINE | ID: mdl-35993382

Assuntos

Antineoplásicos; Proteínas Reguladoras de Apoptose; Humanos; Antineoplásicos/farmacologia; Apoptose; Proteínas Reguladoras de Apoptose/metabolismo; Linhagem Celular Tumoral; Proteína de Sequência 1 de Leucemia de Células Mieloides/metabolismo; Patentes como Assunto; Proteínas Proto-Oncogênicas c-bcl-2

Palavras-chave

Apoptosis; BCL-2 protein family; BH3 mimetics; PROTACs; cancer therapy; proteinprotein interactions

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Reguladoras de Apoptose / Antineoplásicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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