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ALSUntangled #65: glucocorticoid corticosteroids.
Goslinga, Jill Ann; Terrelonge, Mark; Bedlack, Richard; Barkhaus, Paul; Barnes, Benjamin; Bertorini, Tulio; Bromberg, Mark; Carter, Gregory; Chen, Amy; Crayle, Jesse; Dimachkie, Mazen; Jiang, Leanne; Levitsky, Gleb; Lund, Isaac; Martin, Sarah; Mcdermott, Christopher; Pattee, Gary; Pierce, Kaitlyn; Ratner, Dylan; Slachtova, Lenka; Sun, Yuyao; Wicks, Paul.
Afiliação
  • Goslinga JA; Neurology Department, University of California San Francisco, San Francisco, CA, USA.
  • Terrelonge M; Neurology Department, University of California San Francisco, San Francisco, CA, USA.
  • Bedlack R; Neurology Department, Duke University, Durham, NC, USA.
  • Barkhaus P; Neurology Department, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Barnes B; Neurology Department, Augusta University Medical College of Georgia, Augusta, GA, USA.
  • Bertorini T; Neurology Department, University of Tennessee Health Science Center, Memphis, TN, USA.
  • Bromberg M; Neurology Department, University of Utah Health, Salt Lake City, UT, USA.
  • Carter G; Physical Medicine and Rehabilitation, Saint Luke's Rehabilitation Institute, Spokane, WA, USA.
  • Chen A; Neurology Department, Medical University of South Carolina, Charleston, SC, USA.
  • Crayle J; Neurology Department, Washington University, St. Louis, MO, USA.
  • Dimachkie M; Neurology Department, University of Kansas Health System, Kansas City, KS, USA.
  • Jiang L; Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, Nedlands, WA, AUS.
  • Levitsky G; Real Health Clinic, Moscow, Russian Federation.
  • Lund I; Green Hope High School, Cary, NC, USA.
  • Martin S; Physical Therapy Department, Duke University, Durham, NC, USA.
  • Mcdermott C; Institute for Translational Neuroscience, The University of Sheffield, Sheffield, SY, UK.
  • Pattee G; Neurology Department, University of Nebraska Medical Center, Lincoln, NE, USA.
  • Pierce K; Undergraduate, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Ratner D; Longmeadow High School, Longmeadow, MA, USA.
  • Slachtova L; Biology and Medical Genetics, Univerzita Karlova Biologicka Sekce, and.
  • Sun Y; Neurology Department, Duke University, Durham, NC, USA.
  • Wicks P; Independent Contractor.
Amyotroph Lateral Scler Frontotemporal Degener ; 24(3-4): 351-357, 2023 05.
Article em En | MEDLINE | ID: mdl-35997522
ABSTRACT
ALSUntangled reviews alternative and off-label treatments for people with amyotrophic lateral sclerosis (PALS). Here we review glucocorticoids. Neuroinflammation plays a prominent role in amyotrophic lateral sclerosis (ALS) pathogenesis, so some hypothesize that glucocorticoids might be an effective ALS therapy through their immunosuppressive effects. In this paper, we review the available evidence for glucocorticoids in ALS, including one pre-clinical study with a genetic mouse model of ALS, nine case reports (ranging from 1 to 26 patients each), and four clinical trials. We also review the possible side effects (including steroid myopathy) and the costs of therapy. We graded the level of evidence as follows Mechanism, D; Pre-Clinical, F; Cases, B; Trials, F; Risks, C. Our review of the current evidence concludes that glucocorticoids do not offer clinical benefit in ALS and confer serious risks. Thus, ALSUntangled does not recommend glucocorticoids as a treatment for ALS.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esclerose Lateral Amiotrófica Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esclerose Lateral Amiotrófica Idioma: En Ano de publicação: 2023 Tipo de documento: Article