Streptothiazolidine B, a new cytotoxic alkaloid produced by Streptomyces violaceoruber.
J Asian Nat Prod Res
; 25(6): 595-602, 2023 Jun.
Article
em En
| MEDLINE
| ID: mdl-36000727
ABSTRACT
A new cytotoxic alkaloid, named streptothiazolidine B (1), together with three known compounds (2-4), were isolated from Streptomyces violaceoruber. The structure of the undescribed compound was established using 1D and 2D NMR, and HRESIMS. Streptothiazolidine B was isolated and identified as an amide alkaloid with a unique thiazolidine side chain and its absolute configuration was determined by a combination of NOESY experiment and ECD analysis. Streptothiazolidine B exhibited significant cytotoxic activities against two human tumor cell lines, Li-7 and A2780, with IC50 values of 7.8, and 9.1 µM. Meanwhile, compound 4 showed obvious cytotoxic activities against four human tumor cell lines, THP-1, HT29, Li-7 and A2780, with IC50 values ranging from 3.1 to 10.2 µM.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Alcaloides
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article