Viscosity increase/gelation of therapeutic IgG monoclonal antibodies induced by Zn<sup>2+</sup>: One possible root cause of clogging of staked-in-needle prefilled syringes.

Fukuda, Masakazu; Yamazaki, Tadao; Ueno, Seiji; Koga, Akiko; Yamanaka, Yuji

Viscosity increase/gelation of therapeutic IgG monoclonal antibodies induced by Zn²⁺: One possible root cause of clogging of staked-in-needle prefilled syringes.

Fukuda, Masakazu; Yamazaki, Tadao; Ueno, Seiji; Koga, Akiko; Yamanaka, Yuji.

Afiliação

Fukuda M; Production Engineering Department, Chugai Pharmaceutical Co. Ltd., 5-5-1 Ukima, Kita-ku, Tokyo 115-8543, Japan. Electronic address: fukuda.masakazu76@chugai-pharm.co.jp.
Yamazaki T; Production Engineering Department, Chugai Pharmaceutical Co. Ltd., 5-5-1 Ukima, Kita-ku, Tokyo 115-8543, Japan.
Ueno S; Production Engineering Department, Chugai Pharmaceutical Co. Ltd., 5-5-1 Ukima, Kita-ku, Tokyo 115-8543, Japan.
Koga A; Production Engineering Department, Chugai Pharmaceutical Co. Ltd., 5-5-1 Ukima, Kita-ku, Tokyo 115-8543, Japan.
Yamanaka Y; CMC Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-ku, Tokyo 115-8543, Japan.

Eur J Pharm Biopharm ; 178: 179-186, 2022 Sep.

Article em En | MEDLINE | ID: mdl-36029938

Assuntos

Anticorpos Monoclonais; Seringas; Anticorpos Monoclonais/química; Elastômeros; Imunoglobulina G/química; Espalhamento a Baixo Ângulo; Viscosidade; Difração de Raios X; Zinco

Palavras-chave

Clogging; Gelation; High concentration; Monoclonal antibody; Viscosity; Zn(2+)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Seringas / Anticorpos Monoclonais Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Seringas / Anticorpos Monoclonais Idioma: En Ano de publicação: 2022 Tipo de documento: Article