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Characterizing differences in psychiatric profiles between male and female veterans with epilepsy and psychogenic non-epileptic seizures.
Sullivan-Baca, Erin; Weitzner, Daniel S; Choudhury, Tabina K; Fadipe, Melissa; Miller, Brian I; Haneef, Zulfi.
Afiliação
  • Sullivan-Baca E; DR Associates of North Texas (Private Researcher), Plano, TX 75093, USA. Electronic address: erinsullivanbaca@gmail.com.
  • Weitzner DS; Mental Health Care Line, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA; Psychology Department, Louisiana State University, Baton Rouge, LA 70803, USA.
  • Choudhury TK; Mental Health Care Line, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA.
  • Fadipe M; Neurology Care Line, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA.
  • Miller BI; Neurology Care Line, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA.
  • Haneef Z; Neurology Care Line, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
Epilepsy Res ; 186: 106995, 2022 10.
Article em En | MEDLINE | ID: mdl-36030730
ABSTRACT

OBJECTIVE:

While previous studies have described psychiatric profiles in patients with psychogenic non-epileptic seizures (PNES) and epileptic seizures (ES), a well-matched comparison between males and females has been lacking. To address this shortcoming, the present study sought to explore sex differences between male and female Veterans with ES and PNES in terms of psychiatric diagnoses, trauma histories, and psychiatric treatment.

METHODS:

A male Veteran sample (PNES n = 87, ES n = 28) was identified matching age and seizure diagnosis with our previously-gathered female Veteran sample (PNES n = 90, ES n = 28). Retrospective chart review was used to obtain demographic, psychiatric, and seizure-related variables. Group differences between PNES and ES were first assessed among males followed by differences between males and females.

RESULTS:

Males with PNES were more likely to receive psychiatric treatment (82.6 % vs. 60.7 %, p = 0.017), be prescribed more psychotropics (1.6 vs. 0.9, p = 0.003), and more likely to have childhood physical abuse (27.9 % vs. 3.6 %, p = 0.007) than those with ES. Compared to PNES, males with ES presented to the epilepsy monitoring unit (EMU) significantly later (12.8 years vs. 6.1 years, p = 0.009), and were prescribed more anti-seizure medications (ASMs) previously (2.1 vs. 0.8, p = 0.009) and currently (1.6 vs. 1.0, p = 0.001). Between males and females with PNES, females evidenced more depression (76.7 % vs. 26.3 %, p < 0.001), borderline personality disorder (18.9 % vs. 4.7 %, p = 0.004), suicidality (65.6 % vs. 33.7 %, p < 0.001), and childhood sexual abuse (37.8 % vs. 11.6 %, p < 0.001), while males had higher rates of substance use disorders (37.2 % vs. 8.9 %, p < 0.001).

SIGNIFICANCE:

A greater psychiatric burden is seen among females compared to males with PNES, especially diagnoses of borderline personality disorder and depression. Higher rates of suicidality and inpatient psychiatric hospitalization may warrant particular consideration in screening and intervention efforts among female Veterans with PNES.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Veteranos / Epilepsia Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Veteranos / Epilepsia Idioma: En Ano de publicação: 2022 Tipo de documento: Article