Impact of the PEG length and PEGylation site on the structural, thermodynamic, thermal, and proteolytic stability of mono-PEGylated alpha-1 antitrypsin.

Liu, Xiao; Kouassi, Kobenan G W; Vanbever, Rita; Dumoulin, Mireille

Liu, Xiao; Kouassi, Kobenan G W; Vanbever, Rita; Dumoulin, Mireille.

Afiliação

Liu X; Advanced Drug Delivery and Biomaterials, Louvain Drug Research Institute, Université catholique de Louvain (UCLouvain), Brussels, Belgium.
Kouassi KGW; Advanced Drug Delivery and Biomaterials, Louvain Drug Research Institute, Université catholique de Louvain (UCLouvain), Brussels, Belgium.
Vanbever R; Advanced Drug Delivery and Biomaterials, Louvain Drug Research Institute, Université catholique de Louvain (UCLouvain), Brussels, Belgium.
Dumoulin M; Department of Life Sciences, InBios, Center for Protein Engineering, Nanobodies to Explore Protein Structure and Functions, University of Liège, Liège, Belgium.

Protein Sci ; 31(9): e4392, 2022 09.

Article em En | MEDLINE | ID: mdl-36040264

Assuntos

Polietilenoglicóis; alfa 1-Antitripsina/química; Humanos; Polietilenoglicóis/química; Proteólise; Termodinâmica

Palavras-chave

PEGylation; alpha-1 antitrypsin (AAT); heat-induced aggregation; proteolysis; thermodynamic stability

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Alfa 1-Antitripsina Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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XML

PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Alfa 1-Antitripsina Idioma: En Ano de publicação: 2022 Tipo de documento: Article