The treatment of knee cartilage lesions: state of the art.
Acta Biomed
; 93(4): e2022099, 2022 08 31.
Article
em En
| MEDLINE
| ID: mdl-36043984
ABSTRACT
The management and repair of knee cartilage lesions currently represents a challenge for the orthopaedic surgeon. Identifiable causes are the characteristics of the involved tissues themselves and the presence of poor vascularization, which is responsible for overall reduced repair capacity. The literature reports three types of cartilage lesions' treatment modalities chondroprotection, chondroreparation and chondrogeneration. The preference for one or the other therapeutic option depends on the pattern of the lesion and the clinical conditions of the patient. Each treatment technique is distinguished by the quality of the restorative tissue that is generated. In particular, the chondrorigeneration represents the last frontier of regenerative medicine, as it aims at the complete restoration of natural cartilage. However, the most recent literature documents good results only in the short and medium terms. In recent years the optimization of chondroregeneration outcomes is based on the modification of the scaffolds and the search for new chondrocyte sources, in order to guarantee satisfactory long-term results.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cartilagem Articular
/
Transplante de Células-Tronco Mesenquimais
/
Traumatismos do Joelho
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article