Bladder Cancer-Derived Small Extracellular Vesicles Promote Tumor Angiogenesis by Inducing HBP-Related Metabolic Reprogramming and SerRS O-GlcNAcylation in Endothelial Cells.

Li, Xinyuan; Peng, Xiang; Zhang, Chunlin; Bai, Xuesong; Li, Yang; Chen, Guo; Guo, Huixia; He, Weiyang; Zhou, Xiang; Gou, Xin

Li, Xinyuan; Peng, Xiang; Zhang, Chunlin; Bai, Xuesong; Li, Yang; Chen, Guo; Guo, Huixia; He, Weiyang; Zhou, Xiang; Gou, Xin.

Afiliação

Li X; Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Peng X; Centre for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
Zhang C; Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Bai X; Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Li Y; Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Chen G; Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Guo H; Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
He W; Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Zhou X; Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Gou X; Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Adv Sci (Weinh) ; 9(30): e2202993, 2022 10.

Article em En | MEDLINE | ID: mdl-36045101

Assuntos

Vesículas Extracelulares; Serina-tRNA Ligase; Neoplasias da Bexiga Urinária; Camundongos; Animais; Glutamina-Frutose-6-Fosfato Transaminase (Isomerizante)/genética; Glutamina-Frutose-6-Fosfato Transaminase (Isomerizante)/metabolismo; Células Endoteliais/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo; Serina-tRNA Ligase/metabolismo; Hexosaminas/metabolismo; Serina/metabolismo; Glucose/metabolismo; Vesículas Extracelulares/metabolismo; Carioferinas; Microambiente Tumoral

Palavras-chave

O-GlcNAcylation; angiogenesis; glutamine-fructose-6-phosphate aminotransferase 1; metabolic reprogramming; small extracellular vesicles

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Serina-tRNA Ligase / Neoplasias da Bexiga Urinária / Vesículas Extracelulares Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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