[International trend regarding immunotoxicity evaluation with New Approach Methods (NAMs)].
Nihon Yakurigaku Zasshi
; 157(5): 340-344, 2022.
Article
em Ja
| MEDLINE
| ID: mdl-36047149
ABSTRACT
We have ongoing projects that are developing New Approach Methods (NAMs) for systematic toxicology. One NAM is to develop the immunotoxicity evaluation with non-animal test methods for the Organisation for Economic Co-operation and Development (OECD)Test Guideline (TG). The development of this evaluation includes the following steps:
1) adverse outcome pathway (AOP), 2) detailed review paper, 3) test methods based on AOP, 4) validation study of test methods for developing TGs, and 5) integrated approaches to testing and assessment (IATA). I believe that the NAMs developed on these steps may enable risk assessment of a chemical with non-animal test methods in near future.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Organização para a Cooperação e Desenvolvimento Econômico
Idioma:
Ja
Ano de publicação:
2022
Tipo de documento:
Article