Poor morphology of inner cell mass increases birth weight and large for gestational age.
Reprod Biomed Online
; 45(5): 890-897, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-36055913
ABSTRACT
RESEARCH QUESTION Can inner cell mass (ICM) and trophectoderm morphological grading, especially ICM and trophectoderm graded C, affect perinatal outcomes? DESIGN:
A retrospective review of medical records of 8946 singletons delivered from vitrified-warmed single blastocyst transfer cycles between January 2009 and December 2020.RESULTS:
Inner cell mass graded C had a higher adjusted birth weight than ICM graded A (0.61 ± 1.06 versus 0.48 ± 1.06; Pâ¯=â¯0.025). Large for gestational age (LGA) increased with decreasing ICM morphological grading (18.96%, 21.88% and 23.38%; grade B versus grade A, Pâ¯=â¯0.013; grade C versus grade A, Pâ¯=â¯0.036) (P < 0.025 was considered statistically significant for multiple pairwise comparisons). Linear regression analysis suggested that ICM morphological grading was significantly associated with adjusted birth weight, with grade C increasing adjusted birth weight compared with grade A (ß 0.13, 95% CI 0.00 to 0.25, Pâ¯=â¯0.043) (P < 0.05 was considered statistically significant for linear regression). Logistic regression analysis suggested that ICM morphological grading was significantly associated with LGA, with grade C increasing LGA compared with grade A (adjusted OR 1.37, 95% CI 1.03 to 1.81). Moreover, blastocysts with ICM graded C had a higher chance of being a male infant compared with ICM graded A (adjusted OR 1.32, 95% CI 1.04 to 1.68).CONCLUSIONS:
Inner cell mass morphological grading was significantly associated with adjusted birth weight and LGA. Poor ICM graded C increased birth weight and LGA.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Blastocisto
/
Transferência Embrionária
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article