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In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice.
Rovai, Alice; Chung, BoMee; Hu, Qingluan; Hook, Sebastian; Yuan, Qinggong; Kempf, Tibor; Schmidt, Florian; Grimm, Dirk; Talbot, Steven R; Steinbrück, Lars; Götting, Jasper; Bohne, Jens; Krooss, Simon A; Ott, Michael.
Afiliação
  • Rovai A; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Chung B; Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Hu Q; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
  • Hook S; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Yuan Q; Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Kempf T; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Schmidt F; Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Grimm D; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  • Talbot SR; Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Steinbrück L; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
  • Götting J; Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
  • Bohne J; Department of Infectious Diseases/Virology, Medical Faculty, University of Heidelberg, Cluster of Excellence CellNetworks, BioQuant BQ0030, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany.
  • Krooss SA; BioQuant, Center for Integrative Infectious Diseases Research (CIID), University of Heidelberg, Heidelberg, Germany.
  • Ott M; Department of Infectious Diseases/Virology, Medical Faculty, University of Heidelberg, Cluster of Excellence CellNetworks, BioQuant BQ0030, Im Neuenheimer Feld 267, 69120, Heidelberg, Germany.
Nat Commun ; 13(1): 5215, 2022 09 05.
Article em En | MEDLINE | ID: mdl-36064805
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adenina / Proteína da Hemocromatose / Hemocromatose Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adenina / Proteína da Hemocromatose / Hemocromatose Idioma: En Ano de publicação: 2022 Tipo de documento: Article