Clinical and economic burden of chronic rhinosinusitis with nasal polyposis: A U.S. administrative claims analysis.
Allergy Asthma Proc
; 43(5): 435-445, 2022 09 01.
Article
em En
| MEDLINE
| ID: mdl-36065104
ABSTRACT
Background:
Limited data exist on the clinical and economic burden of chronic rhinosinusitis with nasal polyposis (CRSwNP).Objective:
To describe patient characteristics, health-care resource utilization (HCRU), and health-care costs among patients with CRSwNP with and without comorbid asthma (primary analysis) and with surgical management of nasal polyps (secondary analysis).Methods:
This was a retrospective study of patients diagnosed with CRSwNP conducted using administrative claims data from January 1, 2013, through March 31, 2019. Study outcomes were assessed over a 2-year follow-up. Results were stratified by baseline asthma status (primary analysis) and presented separately for patients with surgically managed CRSwNP (secondary analysis).Results:
The primary analysis included 10,999 patients with CRSwNP (2649 with asthma, 8350 without asthma). Patients with versus without asthma had higher medication use, HCRU, and all-cause medical costs (mean ± standard deviation $34,667 ± $42,234 versus $27,122 ± $45,573; p < 0.001) across the full follow-up period. CRSwNP-related medical costs were significantly higher for patients with versus without asthma in year 2 of follow-up. In the surgical management analysis (n = 4943), most categories of medication use and CRSwNP-related HCRU declined from baseline levels during follow-up, and CRSwNP-related pharmacy costs in year 2 were less than half of baseline levels.Conclusion:
Patients diagnosed with CRSwNP and asthma had a greater burden of illness than those without asthma. Higher CRSwNP-related medical costs in year 2 of follow-up for patients with asthma may indicate worsening symptoms over time. Among patients with surgically managed CRSwNP, HCRU and costs increased in year 1 of follow-up but decreased below baseline levels in year 2, potentially reflecting improved symptom severity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Sinusite
/
Rinite
/
Pólipos Nasais
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article