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The landscape of aging.
Cai, Yusheng; Song, Wei; Li, Jiaming; Jing, Ying; Liang, Chuqian; Zhang, Liyuan; Zhang, Xia; Zhang, Wenhui; Liu, Beibei; An, Yongpan; Li, Jingyi; Tang, Baixue; Pei, Siyu; Wu, Xueying; Liu, Yuxuan; Zhuang, Cheng-Le; Ying, Yilin; Dou, Xuefeng; Chen, Yu; Xiao, Fu-Hui; Li, Dingfeng; Yang, Ruici; Zhao, Ya; Wang, Yang; Wang, Lihui; Li, Yujing; Ma, Shuai; Wang, Si; Song, Xiaoyuan; Ren, Jie; Zhang, Liang; Wang, Jun; Zhang, Weiqi; Xie, Zhengwei; Qu, Jing; Wang, Jianwei; Xiao, Yichuan; Tian, Ye; Wang, Gelin; Hu, Ping; Ye, Jing; Sun, Yu; Mao, Zhiyong; Kong, Qing-Peng; Liu, Qiang; Zou, Weiguo; Tian, Xiao-Li; Xiao, Zhi-Xiong; Liu, Yong; Liu, Jun-Ping.
Afiliação
  • Cai Y; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Song W; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
  • Li J; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
  • Jing Y; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, College of Life Sciences, Wuhan University, Wuhan, 430071, China.
  • Liang C; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
  • Zhang L; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhang X; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhang W; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Liu B; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • An Y; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
  • Li J; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
  • Tang B; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
  • Pei S; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China.
  • Wu X; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Liu Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Zhuang CL; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
  • Ying Y; Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, 100191, China.
  • Dou X; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Chen Y; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
  • Xiao FH; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
  • Li D; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
  • Yang R; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China.
  • Zhao Y; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Wang Y; School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing, 100084, China.
  • Wang L; Colorectal Cancer Center/Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, 200072, China.
  • Li Y; Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
  • Ma S; International Laboratory in Hematology and Cancer, Shanghai Jiaotong University School of Medicine/Ruijin Hospital, Shanghai, 200025, China.
  • Wang S; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China.
  • Song X; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
  • Ren J; State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
  • Zhang L; CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China.
  • Wang J; Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
  • Zhang W; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
  • Xie Z; Aging and Vascular Diseases, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang, 330031, China.
  • Qu J; Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China.
  • Wang J; Institute of Ageing Research, Hangzhou Normal University, School of Basic Medical Sciences, Hangzhou, 311121, China.
  • Xiao Y; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Tian Y; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
  • Wang G; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
  • Hu P; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. mashuai@ioz.ac.cn.
  • Ye J; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. mashuai@ioz.ac.cn.
  • Sun Y; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. mashuai@ioz.ac.cn.
  • Mao Z; Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. wangsi@xwh.ccmu.edu.cn.
  • Kong QP; Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. wangsi@xwh.ccmu.edu.cn.
  • Liu Q; The Fifth People's Hospital of Chongqing, Chongqing, 400062, China. wangsi@xwh.ccmu.edu.cn.
  • Zou W; MOE Key Laboratory of Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Neurodegenerative Disorder Research Center, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Te
  • Tian XL; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. renjie@big.ac.cn.
  • Xiao ZX; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. renjie@big.ac.cn.
  • Liu Y; University of Chinese Academy of Sciences, Beijing, 100049, China. renjie@big.ac.cn.
  • Liu JP; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhangliang01@sibs.ac.cn.
Sci China Life Sci ; 65(12): 2354-2454, 2022 12.
Article em En | MEDLINE | ID: mdl-36066811
ABSTRACT
Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on "healthy aging" raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Neoplasias Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Neoplasias Idioma: En Ano de publicação: 2022 Tipo de documento: Article