Discovery of the Novel 1<i>H</i>-Pyrrolo[2,3-<i>b</i>]pyridine Derivative as a Potent Type II CDK8 Inhibitor against Colorectal Cancer.

Zhang, Xing Xing; Xiao, Yun; Yan, Yao Yao; Wang, Yu Meng; Jiang, Han; Wu, Lei; Shi, Jing-Bo; Liu, Xin Hua

Discovery of the Novel 1H-Pyrrolo[2,3-b]pyridine Derivative as a Potent Type II CDK8 Inhibitor against Colorectal Cancer.

Zhang, Xing Xing; Xiao, Yun; Yan, Yao Yao; Wang, Yu Meng; Jiang, Han; Wu, Lei; Shi, Jing-Bo; Liu, Xin Hua.

Afiliação

Zhang XX; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, P. R. China.
Xiao Y; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, P. R. China.
Yan YY; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, P. R. China.
Wang YM; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, P. R. China.
Jiang H; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, P. R. China.
Wu L; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, P. R. China.
Shi JB; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, P. R. China.
Liu XH; School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, P. R. China.

J Med Chem ; 65(18): 12095-12123, 2022 09 22.

Article em En | MEDLINE | ID: mdl-36068975

Assuntos

Antineoplásicos; Neoplasias Colorretais; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Neoplasias Colorretais/patologia; Quinase 8 Dependente de Ciclina; Desenho de Fármacos; Xenoenxertos/química; Xenoenxertos/metabolismo; Humanos; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/uso terapêutico; Piridinas/farmacologia; Piridinas/uso terapêutico; Relação Estrutura-Atividade; beta Catenina/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Antineoplásicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Antineoplásicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article