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Effect of LHRH analogs on lower urinary tract symptoms associated with advanced prostate cancer in real clinical practice: ANALUTS study.
Morote, Juan; Gómez-Caamaño, Antonio; de Celis, Raúl Poza; Gómez-Veiga, Francisco; Ciria, Juan P; Calleja, Jesús; Extramiana, Javier; Pérez-Sampietro, Maria; Perrot, Valerie; Angulo, Javier C.
Afiliação
  • Morote J; Department of Urology, Vall d'Hebrón Hospital and Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Gómez-Caamaño A; Department of Radiation Oncology, Hospital Clínico Universitario de Santiago de Compostela, La Coruña, Spain.
  • de Celis RP; Department of Radiation Oncology, Hospital Txagorritxu HUA, Álava, Spain.
  • Gómez-Veiga F; Department of Urology, Complexo Hospitalario Universitario A Coruña, Spain.
  • Ciria JP; Department of Radiation Oncology, Hospital Universitario Donostia, San Sebastián, Spain.
  • Calleja J; Department of Urology, Hospital Clínico Universitario Valladolid, Valladolid, Spain.
  • Extramiana J; Department of Urology, Hospital Txagorritxu HUA, Álava, Spain.
  • Pérez-Sampietro M; Ipsen Pharma, Barcelona, Spain.
  • Perrot V; Ipsen Pharma, Boulogne, France.
  • Angulo JC; Clinical Department, Hospital Universitario de Getafe, Universidad Europea de Madrid, Madrid, Spain.
Neurourol Urodyn ; 41(8): 1824-1833, 2022 11.
Article em En | MEDLINE | ID: mdl-36069170
ABSTRACT

AIMS:

To estimate the prevalence of lower urinary tract symptoms (LUTS) in patients with prostate cancer scheduled to receive LHRH analogs, and to assess the effectiveness of LHRH analogs on LUTS in patients presenting moderate/severe symptoms.

METHODS:

Prospective, noninterventional, multicenter study conducted at 28 centers in Spain and Portugal. LUTS were evaluated using the International Prostate Symptom Score (IPSS) at baseline, 24 and 48 weeks after initiation of treatment. Subanalyses were performed according to age and concomitant treatment (radiotherapy, alpha-blockers, and antiandrogens).

RESULTS:

A total of 354 patients were treated with LHRH analogs for 48 weeks. The percentage of patients with moderate/severe LUTS (IPSS > 7) decreased from 60.2% (n = 213/354) at baseline to 52.8% (n = 187/354) at Week 48. Among patients with moderate/severe LUTS at baseline 73.7% (n = 157/213) still had moderate/severe LUTS at Week 48; percentage reductions of patients with LUTS at Week 48 were statistically significant (p < 0.05) overall and by age or concomitant treatment, except for alpha-blockers (84.2% patients receiving them still had moderate/severe LUTS at Week 48). All IPSS items, including quality of life for urinary symptoms, improved throughout the study. The only predictor of response to treatment with LHRH analogs that improved IPSS by 3 points after 48 weeks was baseline testosterone levels. Lower baseline testosterone levels were associated with greater improvement in IPSS after treatment with LHRH analogs (odds ratio 0.998, 95% confidence interval 0.996-1.000, p = 0.0277).

CONCLUSION:

LHRH analogs have a positive effect in patients with locally advanced or metastatic prostate cancer presenting moderate/severe LUTS regardless of age or concomitant treatment received (radiotherapy, antiandrogens, or alpha-blockers).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hiperplasia Prostática / Neoplasias da Próstata / Sintomas do Trato Urinário Inferior Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hiperplasia Prostática / Neoplasias da Próstata / Sintomas do Trato Urinário Inferior Idioma: En Ano de publicação: 2022 Tipo de documento: Article