Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver.

Bozukova, Mihaela; Nikopoulou, Chrysa; Kleinenkuhnen, Niklas; Grbavac, Dora; Goetsch, Katrin; Tessarz, Peter

Bozukova, Mihaela; Nikopoulou, Chrysa; Kleinenkuhnen, Niklas; Grbavac, Dora; Goetsch, Katrin; Tessarz, Peter.

Afiliação

Bozukova M; Max Planck Research Group 'Chromatin and Ageing', Max Planck Institute for Biology of Ageing, Cologne, Germany.
Nikopoulou C; Max Planck Research Group 'Chromatin and Ageing', Max Planck Institute for Biology of Ageing, Cologne, Germany.
Kleinenkuhnen N; Max Planck Research Group 'Chromatin and Ageing', Max Planck Institute for Biology of Ageing, Cologne, Germany.
Grbavac D; Faculty of Medicine, Institute of Medical Statistics and Computational Biology, University of Cologne, Cologne, Germany.
Goetsch K; Max Planck Research Group 'Chromatin and Ageing', Max Planck Institute for Biology of Ageing, Cologne, Germany.
Tessarz P; Max Planck Research Group 'Chromatin and Ageing', Max Planck Institute for Biology of Ageing, Cologne, Germany.

Mol Syst Biol ; 18(9): e11002, 2022 09.

Article em En | MEDLINE | ID: mdl-36082605

Assuntos

Envelhecimento; Cromatina; RNA Polimerase II; Envelhecimento/genética; Envelhecimento/metabolismo; Animais; Cromatina/genética; Cromatina/metabolismo; Fígado/metabolismo; Camundongos; Regiões Promotoras Genéticas; RNA Polimerase II/genética; RNA Polimerase II/metabolismo; Transcrição Gênica

Palavras-chave

aging; chromatin architecture; nascent transcription; promoter-proximal pausing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Polimerase II / Envelhecimento / Cromatina Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Polimerase II / Envelhecimento / Cromatina Idioma: En Ano de publicação: 2022 Tipo de documento: Article